SLCO1B1 (OATP-C)

From PubPK

OATP1B1 (previously called OATPC, LST-1 or OATP2; gene symbol: SLCO1B1) is found to be specifically and highly expressed at the basolateral (sinusoidal) plasma membrane of hepatocytes and is considered to be one of the most important hepatic uptake transporters (Hsiang et al., 1999; König et al., 2000; Abe et al., 1999).

See Also

• Drug Transporters
• OATP1B3

References

• Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S and Yawo H (1999) Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 J Biol Chem 274:17159-17163.
• Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP and Kirchgessner TG (1999) A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters J Biol Chem 274:37161-37168.
• König J, Cui Y, Nies AT and Keppler D (2000) A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane Am J Physiol Gastrointest Liver Physiol 278:G156-G164.