SLC22A1 (OCT1)

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OCT1 (SLC22A1)

Contents 1 Tissue distribution 2 Substrates 3 Inhibitors 4 See also 5 References

Tissue distribution

In humans, OCT1 is predominantly expressed in the liver (Gorboulev et al. 1997; Zhang et al. 1997).

Substrates

• Pentamidine is a substrate of OCT1 (Ming et al. 2009).

Inhibitors

• Pentamidine is a potent inhibitor for all three OCT isoforms: OCT1, OCT2, and OCT3 (Ming et al. 2009).

See also

• OCTs
• OCT2 (SLC22A2)
• OCT3 (SLC22A3)

References

• Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, and Koepsell H (1997) Cloning and characterization of two human polyspecific organic cation transporters DNA Cell Biol 16:871–881.
• Ming X, Ju W, Wu H, Tidwell RR, Hall JE, Thakker DR (2009) Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters Drug Metab Dispos 37:424-30.
• Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, and Giacomini KM (1997) Cloning and functional expression of a human liver organic cation transporter Mol Pharmacol 51:913–921.