CYP3A4

From PubPK

CYP3A4 is the most abundant CYP3A isoform expressed in human liver (Shimada et al. 1994) and gut (Paine et al. 1997; Zhang et al. 1999; Paine et al. 2006).

Contents 1 Function 2 Pharmacogenomics 3 Substrates 4 Inhibitors 5 Inducers 6 See also 7 References

Function

Pharmacogenomics

to be updated

Substrates

• Alprazolam
• Diltiazem
• Midazolam
• Nifedipine
• Sildenafil
• Triazolam

Inhibitors

• Itraconazole
• Ketoconazole

Inducers

• Carbamazepine
• Rifampicin

See also

• Cytochrome P450s (CYPs)
• CYP3A5

References

• Paine MF, Hart HL, Ludington SS, Haining R, Rettie AE and Zeldin DC (2006) The human intestinal cytochrome P450 "pie" Drug Metab Dispos 34:880-886.
• Paine MF, Khalighi M, Fisher JM, Shen DD, Kunze KL, Marsh CL, Perkins JD and Thummel KE (1997) Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism J Pharmacol Exp Ther 283:1552-1562.
• Shimada T, Yamazaki H, Mimura M, Inui Y and Guengerich FP (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians J Pharmacol Exp Ther 270:414-423.
• Zhang QY, Dunbar D, Ostrowska A, Zeisloft S, Yang J and Kaminsky LS (1999) Characterization of human small intestinal cytochromes P-450 Drug Metab Dispos 34:880-886.